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KMID : 0360220070480030348
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Journal of the Korean Ophthalmological Society
2007 Volume.48 No. 3 p.348 ~ p.355
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Changes of Tear Film and Ocular Surface with Time after Penetrating Keratoplasty
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Kang In-Seong
You In-Cheon
Yoon Kyung-Chul
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Abstract
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Purpose: To evaluate the parameters of tear function and ocular surface changes with time course after penetrating keratoplasty (PKP).
Methods: Corneal sensitivity test (CST), tear film break-up time (BUT), basal tear secretion test (BST), tear clearance test (Tcr), fluorescein staining and conjunctival impression cytology were evaluated in 21 eyes of 21 patients who underwent PKP at 1, 3 and 6 months postoperatively.
Results: CST (p=0.02), BST (p=0.04), fluorescein scoring (p=0.03), and goblet cell density (p=0.03) showed improving tendency during 6 month after surgery, but BUT (p=0.11), Tcr (p=0.65) and squamous metaplasia (p=0.20) did not change significantly. One month after surgery, CST (p<0.01), BUT (p=0.01), BST (p<0.01), and goblet cell density (p=0.01) were lower, while fluorescein staining score (p<0.01) and the grade of squamous metaplasia (p=0.03) were higher in PKP group. Six months after surgery, CST (p<0.01) and goblet cell density (p=0.04) were lower, and fluorescein staining score (p<0.01) was higher in PKP group.
Conclusions: Tear film and ocular surface are compromised after PKP and improved gradually during postoperative 6 months. However, these parameters were not recovered completely to the normal level. J Korean Ophthalmol Soc 48(3):348-355, 2007
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KEYWORD
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Ocular surface, Pentrating keratoplasty, Tear film
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